Recent studies on non-invasive biomarkers useful in biliary atresia – a literature review

  • Anna Lew-Tusk Department of Neonatology and Neonatal Intensive Care Unit, St Wojciech Hospital, Gdańsk, Poland
  • Marta Pęksa Department of Obstetrics, Medical University of Gdansk, Gdańsk, Poland
  • Teresa Stachowicz-Stencel Department of Pediatrics, Hematology and Oncology, Medical University of Gdansk, Gdańsk, Poland


The aim of this review is to specify new potential reliable and non-invasive methods for the diagnosis of biliary atresia (BA) that could shorten the way to diagnose BA, and finally the surgical treatment. Apart from the biomarkers that have been proven helpful and are used nowadays in neonatal wards, there are several new potential biomarkers that researchers have found to be helpful in the diagnosis of biliary atresia. Circulating microRNAs, matrix metalloproteinase-7, stool proteins, interleukin-33, Th17-associated cytokines, urinary metabolomics, anti-smooth muscle antibodies, heat shock proteins 90 and positive biliary epithelial cells CD56 are among those presented in this summary. These markers may play a new significant role in BA diagnosis. The described methods include Nomogram, Circulating microRNAs (miRNAs), Matrix metalloproteinase-7 (MMP-7), Stool proteins, Interleukin-33 (IL-33), Th17-associated cytokines, Alpha-aminoadipic acid and N-acetyl-d-mannosamine in urine, Anti-smooth muscle antibodies (ASMA), Heat shock proteins 90 (HSP90), Positive biliary epithelial cells CD56.