Hyaluronic acid concentration in the middle ear fluid as an indicator of severity of the secretory otitis in newborns with cleft palate

Karel Kotaška; Lenka Hanousková; Richard Průša; Jiří Borský; Petra Dytrych; Michal Jurovčík

doi:10.18388/abp.2020_5672

Hyaluronic acid concentration in the middle ear fluid as an indicator of severity of the secretory otitis in newborns with cleft palate

Karel Kotaška Department of Medical Chemistry and Clinical Biochemistry, 2nd Medical Faculty, Charles University, University Hospital Motol, Prague, Czech Republic
Lenka Hanousková Department of Medical Chemistry and Clinical Biochemistry, 2nd Medical Faculty, Charles University, University Hospital Motol, Prague, Czech Republic
Richard Průša Department of Medical Chemistry and Clinical Biochemistry, 2nd Medical Faculty, Charles University, University Hospital Motol, Prague, Czech Republic
Jiří Borský Department of ENT, 2nd Medical Faculty, Charles University, University Hospital Motol, Prague, Czech Republic
Petra Dytrych Department of ENT, 2nd Medical Faculty, Charles University, University Hospital Motol, Prague, Czech Republic
Michal Jurovčík Department of ENT, 2nd Medical Faculty, Charles University, University Hospital Motol, Prague, Czech Republic

DOI: https://doi.org/10.18388/abp.2020_5672

Abstract

The aim of the study was to investigate the hyaluronic acid concentration in middle ear fluid of patients with cleft palate as an indicator of the severity of the disease. Hyaluronic acid was examined in the middle ear fluid of 65 children (48 boys and 17 girls) subjected to cleft lip surgery in neonatal period up to 10 days of age. Patients were divided into 3 groups according to the course of the disease. First group consists of 15 patients with favorable course, second group consist of 25 patients with moderate course, third group included 25 patients with an adverse course. Hyaluronic acid levels were determined by commercially available immunoassay. The concentrations of hyaluronic acid in the middle ear fluid were as follows (mean+SEM): favorable course: 14253+2393 µg/l, moderate course: 7503+1345 µg/l, adverse course: 5905+2393 µg/l. Patients with adverse course and moderate course had significantly decreased hyaluronic acid levels in middle ear fluid compared to the patients with favorable course (P=0.02 and P=0.0018). Hyaluronic acid concentration is related to the course of the disease and the lowest values are most frequent in patients with an adverse course.

pdf
html

Published

2021-09-06

Issue

Vol. 68 No. 4 (2021)

Section

Articles

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Acta Biochimica Polonica is an open access quarterly and publishes four issues a year. All contents are distributed under the Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0) license. Everybody may use the content following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made, ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original. There are no additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.