Isoxanthanol has protective and anti-inflammatory effects on subchondral bone deterioration in experimental osteoarthritic rat model

Xin li; Jie Yu; Yan Zhao; Yating Bai; Lixin Fu; Zilong Ma; Shuqin Zhang

doi:10.18388/abp.2020_5634

Isoxanthanol has protective and anti-inflammatory effects on subchondral bone deterioration in experimental osteoarthritic rat model

Xin li Department of Orthopedics, South of Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Huangcun, Daxing District, Beijing 100053, China
Jie Yu Department of Orthopedics, South of Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Huangcun, Daxing District, Beijing 100053, China
Yan Zhao Department of Orthopedics, South of Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Huangcun, Daxing District, Beijing 100053, China
Yating Bai Department of Emergency, People’s Hospital of Beijing Daxing District, Daxing District, Beijing 102600, China
Lixin Fu Department of Orthopedics, South of Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Huangcun, Daxing District, Beijing 100053, China
Zilong Ma Department of Orthopedics, South of Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Huangcun, Daxing District, Beijing 100053, China
Shuqin Zhang Department of Orthopedics, South of Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Huangcun, Daxing District, Beijing 100053, China

DOI: https://doi.org/10.18388/abp.2020_5634

Abstract

In the present study isoxanthanol was investigated for treatment of monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in vivo. The study demonstrated that isoxanthanol inhibited excessive release of interleukin-6, NO and PGE2 in RAW264.7 cells treated with LPS in dose dependent manner. The effects of isoxanthanol were examined in a rat model of osteoarthritis (OA) and observed to ameliorate inflammatory damage and protect against OA. Moreover, in vivo data also confirmed inhibition of interleukin-6, NO and PGE2 levels in LPS-induced OA-rats. Deterioration of knee subchondral bone in LPS-induced OA-rats was also prevented effectively by isoxanthanol-treatment. Therefore, isoxanthanol prevents subchondral bone deterioration in OA rats via targeting inflammatory processes.

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Published

2022-02-07

Issue

Vol. 69 No. 1 (2022)

Section

Articles

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