Impact of diet and synbiotics on selected gut bacteria and intestinal permeability in individuals with excess body weight – A Prospective, Randomized Study

Agata Janczy; Ewa Aleksandrowicz-Wrona; Zdzisław Kochan; Sylwia Małgorzewicz

doi:10.18388/abp.2020_5443

Impact of diet and synbiotics on selected gut bacteria and intestinal permeability in individuals with excess body weight – A Prospective, Randomized Study

Agata Janczy Department of Nutritional Biochemistry, Medical University of Gdansk, Gdańsk, Poland https://orcid.org/0000-0002-8504-6213
Ewa Aleksandrowicz-Wrona Department of Clinical Nutrition, Medical University of Gdansk, Gdańsk, Poland
Zdzisław Kochan Department of Nutritional Biochemistry, Medical University of Gdansk, Gdańsk, Poland
Sylwia Małgorzewicz Department of Clinical Nutrition, Medical University of Gdansk, Gdańsk, Poland

DOI: https://doi.org/10.18388/abp.2020_5443

Abstract

Overweight and obese individuals may have leaky intestinal barrier and microbiome dysbiosis. The aim of this study was to determine whether body mass reduction with diet and synbiotics in an adult person with excess body mass has an influence on the gut microbiota and zonulin concentration. The study was a single blinded trial. 60 persons with excess body mass were examined. Based on randomization, patients were qualified either to the intervention group (Synbiotic group) or to the control group (Placebo group). Anthropometric measurements, microbiological assessment of faecal samples and zonulin concentration in the stool were performed before and after observation. After 3-months, an increase in the variety of intestinal bacteria (increase in the Shannon-Weaver index and the Simpson index) and a decrease in concentration of zonulin in faecal samples were observed in the Synbiotic group. Also, statistically significant correlation between zonulin and Bifidobacterium spp. (Spearman test, R=–0.51; p=0.0040) was noticed. There were no significant relationships between the body mass, BMI and changes in the intestinal microbiota or zonulin concentrations. The use of diet and synbiotics improved the condition of the microbiota and intestinal barrier in patients in the Synbiotic group.

Author Biographies

Ewa Aleksandrowicz-Wrona, Department of Clinical Nutrition, Medical University of Gdansk, Gdańsk, Poland

Department of Clinical Nutrition

Zdzisław Kochan, Department of Nutritional Biochemistry, Medical University of Gdansk, Gdańsk, Poland

Department of Nutritional Biochemistry

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Published

2020-12-16

Issue

Vol. 67 No. 4 (2020)

Section

Articles

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