Resveratrol administration prevents radiation-related changes in metabolic profiles of hearts 20 weeks after irradiation of mice with a single 2 Gy dose

Michalina Gramatyka; Piotr Widłak; Dorota Gabryś; Roland Kulik; Maria Sokół

doi:10.18388/abp.2020_5403

Resveratrol administration prevents radiation-related changes in metabolic profiles of hearts 20 weeks after irradiation of mice with a single 2 Gy dose

Michalina Gramatyka Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland https://orcid.org/0000-0002-9573-2479
Piotr Widłak Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland https://orcid.org/0000-0001-5099-4726
Dorota Gabryś Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland https://orcid.org/0000-0001-9096-2788
Roland Kulik Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland
Maria Sokół Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland https://orcid.org/0000-0003-1611-8241

DOI: https://doi.org/10.18388/abp.2020_5403

Abstract

We aimed to evaluate whether resveratrol affects radiation-induced changes in metabolite profiles of the mouse heart. Hearts were irradiated in vivo with a single 2 Gy dose during the resveratrol administration and metabolite profiles of heart tissue were analyzed by the untargeted HR-MAS NMR approach twenty weeks after irradiation. The administration of resveratrol mitigated the radiation-induced decline in the content of choline-containing compounds and unsaturated lipids, which might reflect the stabilization of cell membrane structure against radiation-related damage. Results obtained with this mouse model suggest that the resveratrol supplementation may prevent metabolic changes related to radiation-induced damage in the heart.

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Published

2020-12-17

Issue

Vol. 67 No. 4 (2020)

Section

Articles

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