Abnormal level of paxillin in cervical cancer cells is involved in tumor progression and invasion

Hongqing Gu; Jing Wen

doi:10.18388/abp.2020_5379

Abnormal level of paxillin in cervical cancer cells is involved in tumor progression and invasion

Hongqing Gu Department of Gynecology, Baodi District People’s Hospital, Tianjin, 301800, China
Jing Wen Department of Women’s Insurance Guidance, Women’s And Children’s Health Center, Tianjin, 300070, Chin

DOI: https://doi.org/10.18388/abp.2020_5379

Abstract

Human papillomavirus (HPV) is the primary causative agent for the uterine cervical cancer. The expression of oncoproteins E6/E7 promotes apoptosis inhibition and increases the risk of cervical cancer progression. Some research reported that elevated expression of paxillin (PXN) stimulated cancer growth and invasion. However, the clinical significance of PXN in cervical cancer has not been well characterized so far. We found that PXN mRNA expression and protein level are significantly upregulated in cervical cancer cells compared to adjacent normal cells. Furthermore, the paxillin over-expression was correlated with potential of tumorigenesis and invasion. Cervical cancer cells with increased paxillin expression had an ability to form more tumor clones and were characterized by higher invasiveness as well. Therefore, our findings suggest that paxillin may act as an important prognostic factor for cervical cancer patients as it promotes tumor regeneration and invasion.

pdf
html

Published

2021-02-20

Issue

Vol. 68 No. 1 (2021)

Section

Articles

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Acta Biochimica Polonica is an open access quarterly and publishes four issues a year. All contents are distributed under the Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0) license. Everybody may use the content following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made, ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original. There are no additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.