Cholesterol (Blood lipid) lowering potential of Rosuvastatin chitosan nanoparticles for atherosclerosis: Preclinical study in rabbit model

Lin  Chen; Caihong  Wang; Yuanchu Wu

doi:10.18388/abp.2020_5186

Cholesterol (Blood lipid) lowering potential of Rosuvastatin chitosan nanoparticles for atherosclerosis: Preclinical study in rabbit model

Lin Chen Department of Cardiology, Affiliated Wujiang Hospital of Nantong University, Suzhou, Jiangsu, China 215200
Caihong Wang Department of Cardiology, Affiliated Wujiang Hospital of Nantong University, Suzhou, Jiangsu, China 215200
Yuanchu Wu Department of Cardiology, Affiliated Wujiang Hospital of Nantong University, Suzhou, Jiangsu, China 215200

DOI: https://doi.org/10.18388/abp.2020_5186

Abstract

Atherosclerosis is the condition of narrowing of arteries due to plaque buildup on the artery walls. Aortic valve calcification (AVC) is one of the reasons of atherosclerosis which leads to narrowing at the opening of the aortic valve which is commonly referred as Aortic valve stenosis (AS). The Rosuvastatin-chitosan (ROS-chitosan) nanoparticles were prepared using ionotropic gelation method. Nanoparticulate formulation was optimized by 3 factor, 2 level full factorial design to find the effect of independent variables on particle size and percentage encapsulation efficiency. Particle size, encapsulation efficiency, scanning electron microscopy, in vitro drug release of nanoparticles was determined. The adult male rabbit of 4–5 months old were chosen for the study. Hypercholesterolemia was induced in experimental animals by administering diet with Cholesterol and Cholic acid (1.25 % and 0.5% respectively.) Blood lipid profile, interleukin 6 levels and histopathological study was performed. Rosuvastatin was found to be significantly effective in lowering the blood lipid levels. It helps to attenuate atherosclerosis as well as calcification of various valve tissues in experimental animals.

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Published

2020-10-22

Issue

Vol. 67 No. 4 (2020)

Section

Articles

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