Interaction of iron ions with melanin

Andrzej Czesław Żądło; Tadeusz Sarna

doi:10.18388/abp.2019_2889

Interaction of iron ions with melanin

Andrzej Czesław Żądło Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków https://orcid.org/0000-0001-7301-0013
Tadeusz Sarna Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland https://orcid.org/0000-0002-7693-5756

DOI: https://doi.org/10.18388/abp.2019_2889

Abstract

One of the antioxidant roles of melanin is binding redox-active transition metal ions. The aim of this study was to examine the redox reactions accompanying iron binding by melanin. Two kinds of synthetic eumelanin were mixed with iron (II) and iron (III) in the presence and absence of citrate and ADP in the aerobic and anaerobic system. The iron binding was examined by electron paramagnetic resonance (EPR) spectroscopy and thiocyanate assay. Obtained results indicate that although melanin reduces iron (III) that is unbound to this polymer, binding of iron (II) is accompanied by its oxidation by melanin.

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Published

2019-12-11

Issue

Vol. 66 No. 4 (2019): Part I and Part II - FEBS

Section

Articles

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