Novel combinatorial transdermal drug delivery of alendronate with risedronate for the treatment of osteoporosis

  • Fanguo Kong Department of minimally invasive spine surgery, Luoyang Orthopedic Hospital of Henan Province, Zhengzhou City, Henan, 450018, China
  • Bin Jia Integrated Orthopedic Department of Traditional Chinese Medicine (TCM) and Western Medicine Hong-Hui Hospital, Xi’an Jiaotong University College of Medicine, Xi’an City, Shaanxi, 710054, China
  • Peng Cui Deparment of Orthopedics, Beijing Tongren Hospital, Biejing, China
  • Duojun Wang Department of Orthopedics, Shidong Hospital, Yangpu District, Shanghai, 200438, China


The presented investigation explores the efficiency of novel transdermal drug delivery system of combination of two drugs i.e risedronate and alendronate in the treatment of osteoporosis. The nanoparticulate transdermal patch was prepared using PLGA as principle polymer which has been found to be suitable for drug delivery. The novel formulation system was found to be more efficient in lowering and maintaining the plasma calcium at a normal level when compared to a pure drug in a study carried out on an excised rat skin.