Biochemistry and computer-generated graph comparison of the structural and nonstructural proteins of Spanish-1918 Influenza, pandemic-2009, and bird flu viruses

Gusti Ngurah Mahardika; Nyoman I. Suartha; Gusti A. Y. Kencana; Ida B. K. Suardana; Wisnu W. Mahardika; Nyoman S. Budayanti

doi:10.18388/abp.2019_2795

Biochemistry and computer-generated graph comparison of the structural and nonstructural proteins of Spanish-1918 Influenza, pandemic-2009, and bird flu viruses

Gusti Ngurah Mahardika Virology Laboratory, Faculty of Veterinary Medicine Udayana University, Denpasar, Bali, Indonesia https://orcid.org/0000-0001-5525-0793
Nyoman I. Suartha Animal Hospital, Faculty of Veterinary Medicine Udayana University, Denpasar, Bali, Indonesia
Gusti A. Y. Kencana Virology Laboratory, Faculty of Veterinary Medicine Udayana University, Denpasar, Bali, Indonesia
Ida B. K. Suardana Virology Laboratory, Faculty of Veterinary Medicine Udayana University, Denpasar, Bali, Indonesia
Wisnu W. Mahardika Faculty of Visual Communication Design of Bina Nusantara University, Tanggerang–Banten, Indonesia
Nyoman S. Budayanti Microbiology Department, Faculty of Medicine Udayana University, Denpasar, Bali, Indonesia

DOI: https://doi.org/10.18388/abp.2019_2795

Abstract

A potential emergence of deadly pandemic influenza viruses is unpredictable and most of them have emerged with no forewarning. The distinct epidemiological and pathological patterns of the Spanish (H1N1), pandemic-2009 (H1N1), and avian influenza (H5N1), known as bird flu, viruses may allow us to develop a ‘template’ for possible emergence of devastating pandemic strains. Here, we provide a detailed molecular dissection of the structural and nonstructural proteins of this triad of viruses. GenBank data for three representative strains were analyzed to determine the polymorphic amino acids, genetic distances, isoelectric points, hydrophobicity plot, and protein modeling of various proteins. We propose that the most devastating pandemic strains may have untruncated PB1-F2 protein with unique residues, highly cleavable HA, and a basic NS1. Any newly emerging strain should be compared with these three strains, so that resources can be directed appropriately.

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Published

2019-07-24

Issue

Vol. 66 No. 3 (2019)

Section

Articles

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