Genistein modulates gene activity in psoriatic patients

Elwira Smolińska; Grzegorz Węgrzyn; Magdalena Gabig-Cimińska

doi:10.18388/abp.2018_2772

Genistein modulates gene activity in psoriatic patients

Elwira Smolińska Department of Medical Biology and Genetics, University of Gdańsk, Gdańsk, Poland
Grzegorz Węgrzyn Department of Molecular and Cellular Biology, Intercollegiate Faculty of Biotechnology UG-MUG, Gdańsk, Poland
Magdalena Gabig-Cimińska 1Department of Medical Biology and Genetics, University of Gdańsk, Gdańsk, Poland; 2Institute of Biochemistry and Biophysics, Polish Academy od Sciences, Gdańsk, Poland

DOI: https://doi.org/10.18388/abp.2018_2772

Abstract

Despite the impressive advancements in the treatment of psoriasis over the past two decades, there is still a need for further improvement. As previously shown in the literature, genistein (5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one), naturally occurring plant compound displays multidirectional action, also in relation to alleviating psoriasis symptoms. In this work we focused our attention on genistein impact on expression of genes when treating moderate-to-severe psoriasis patients. Testing the effects of this isoflavone on transcript levels in both skin specimens and peripheral blood cells of four psoriatic subjects, we found that this compound modulated activities of genes coding for anti-psoriatic members and anti-inflammatory mediators of inflammation. It impairs the activity of certain genes which are overexpressed in psoriasis, while stimulating the expression of other transcripts that are repressed in dermatosis.

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Published

2019-02-28

Issue

Vol. 66 No. 1 (2019)

Section

Articles

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