Severe clinical toxicity caused by 25I-NBOMe confirmed analytically using LC-MS-MS method

  • Wojciech Waldman Department of Clinical Toxicology, Medical University of Gdansk, Gdansk, Poland Pomeranian Center of Toxicology, Gdansk, Poland
  • Maria Kała Institute of Forensic Research, Krakow, Poland
  • Wojciech Lechowicz Institute of Forensic Research, Krakow, Poland
  • Dominika Gil Institute of Forensic Research, Krakow, Poland
  • Jacek Sein Anand Department of Clinical Toxicology, Medical University of Gdansk, Gdansk, Poland Pomeranian Center of Toxicology, Gdansk, Poland

Abstract

Rhabdomyolysis is a relatively rare, but potentially seriouscomplication of various diseases. Muscular injuryand resultant release of electrolytes, myoglobin andother enzymatic proteins e.g. creatine kinase (CK) intocirculation may result in multi-organ failure requiring anextensive treatment. Non-traumatic causes of rhabdomyolysis,like poisonings, appear to be much more frequentthan traumatic causes. We present the case of a patientwho developed exceptionally massive rhabdomyolysis,with CK up to 516 455 U/l, after ingestion of a relativelysmall dose of a novel psychoactive substance knownas “Alice in Wonderland”. Laboratory quantification wasperformed using a validated LC-MS/MS method in awhole blood sample.

Author Biography

Wojciech Waldman, Department of Clinical Toxicology, Medical University of Gdansk, Gdansk, Poland Pomeranian Center of Toxicology, Gdansk, Poland
Wojciech Waldman is an Assistant Professor of Clinical Toxicology at the Medical University of Gdańsk. He received his doctorate in Medical Science from Medical University of Gdańsk. His recent publications include:Poisoning deaths in Poland: types and frequencies reported in Łódź, Kraków, Sosnowiec, Gdańsk, Wrocław and Poznań during 2009-2013. Int. J. Occup. Med. Environ. Health 2017; 30, 897-908. Hyperventilation with maintenance of isocapnia. An "old new" method in carbon monoxide intoxication. PLoS ONE 2017; 12, 1-8.Psychosis associated with acute recreational drug toxicity: a European case series. BMC Psychiatry 2016;16, 293.Drinking "Vodka" or vodka: this is a question. Toxicol. Vitro 2016; 36, 66-70.Repeated self-mutilation of testicles in the context of methamphetamine use: a case report and brief review of literature. J. Forensic Legal Med. 2015; 30, 1-3.Acute intoxication due to tert-amyl alcohol: a case report. Forensic Sci. Int. 2014; 242, 31-33.Hyperventilation with and without maintenance of isocapnia: a comparison of selected gasometric and respiratory parameters. Respir. Physiol. Neurobiol. 2014; 201, 71-74.His current research interests include the rhabdomyolysis and novel psychoactive substances.

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Published
2018-10-18
Section
Articles