Physicochemical properties and cytotoxicity of hydrogels based on Beetosan® containing sage and bee pollen
Currently, more and more attention is being paid to issues related to the environmental protection, waste management as well as to the development of polymers with useful properties. Therefore, present research involved preparation of hydrogels the main component of which was Beetosan® - chitosan derived from the multi-stage processing of died bees. Moreover, hydrogels were additionally modified with natural substances. Based on the research it can be stated that such combination of Beetosan® hydrogel matrix and mentioned additives resulted in a preparation of polymers characterized by negative impact on cancer cells. Finally, it can be concluded that the use of natural-derived reagents and synthesis of polymers using these reagents (as a result of environmentally friendly photopolymerization) lead to the receipt of the materials with unusual properties, with particular emphasis on antitumor activity.
Hasanein P, Felehgari Z, Emamjomeh A (2016) Preventive effects of Salvia officinalis L. against learning and memory deficit induced by diabetes in rats: Possible hypoglycaemic and antioxidant mechanisms. Neurosci. Lett. 622: 72-77. https://doi.org/10.1016/j.neulet.2016.04.045
Cabrera de Oliveira R, Nascimento Queiroz SC, Fernandez Pinto da Luz C, Silveira Porto R, Rath S (2016) Bee pollen as a bioindicator of environmental pesticide contamination. Chemisphere 163: 525-534. https://doi.org/10.1016/j.chemosphere.2016.08.022.
Nemtsev SV, Zueva OY, Khismatullin MR, Albulov AI, Varlamoc VP (2004) Isolation of Chitin and Chitosan from Honeybees. Appl. Biochem. Microbiol. 40(1): 39-43. https://doi.org/ 10.1023/B:ABIM.0000010349.62620.49
Draczyński Z (2008) Honeybee corpses as an available source of chitin. J. Appl. Polym. Sci. 109: 1974-1981. https:/doi.org/10.1002/app.28356
Mucha M. (2010) Chitozan – wszechstronny polimer ze źródeł nieodnawialnych, Wyd.
Alemdaroglu C, Degim Z, Celebi N, Zor F, Ozturk S, Erdogan D (2006) An investigation on burn wound healing in rats with chitosan gel formulation containing epidermal growth factor Burns 32: 319-327. https:/doi.org/ DOI:10.1016/j.burns.2005.10.015
Ma L, Shi Y, Chen Y, Zhao H, Gao C, Han C (2007) In vitro and in vivo biological performance of collagen-chitosan/silicone membrane bilayer dermal equivalent. J. Mater. Sci.: Mater. Med. 18(11): 2185-2191. https:/doi.org/10.1007/s10856-007-3088-4
Tyliszczak B, Drabczyk A, Kudłacik S, Sobczak-Kupiec A (2017) J. Renew. Mater. 5(3-4): 174-179. https:/doi.org/10.7569/JRM.2017.634107
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