NOD1 and NOD2 receptors: integral members of the innate and adaptive immunity system.

  • Halina Antosz Department of Clinical Genetics, Medical University of Lublin, Lublin, Poland.;
  • Magdalena Osiak


NOD-like proteins (NLR) are a specialized group of intracellular receptors, which constitute an essential component of the host innate immune system. They were discovered more than a decade ago, but research on this particular class of microbial detectors is still ongoing to allow for a better understanding of the mechanisms, recognition of microorganisms, transmission of signals, and carrying out the activation of inflammatory signaling pathways. In this review, we discuss the construction of NOD1 and NOD2 receptors, their functions, and significance in the pathogenesis of inflammatory diseases in humans.