Stress granules (SG) and processing bodies (PB) in viral infections.

Magdalena Malinowska; Paulina Niedźwiedzka-Rystwej; Beata Tokarz-Deptuła; Wiesław Deptuła

doi:10.18388/abp.2015_1060

Magdalena Malinowska Department of Immunology, Faculty of Biology, University of Szczecin.;
Paulina Niedźwiedzka-Rystwej Department of Immunology, Faculty of Biology, University of Szczecin.;
Beata Tokarz-Deptuła Department of Microbiology, Faculty of Biology, University of Szczecin, Szczecin, Poland.;
Wiesław Deptuła Department of Microbiology, Faculty of Biology, University of Szczecin, Szczecin, Poland.;

DOI: https://doi.org/10.18388/abp.2015_1060

Abstract

During reaction to stress caused by viral infection, RNA granules are formed in order to protect mRNA. Stress granules (SG) and processing bodies (PB) provide cell homeostasis and mRNA stability. They are formed, for example, during polio virus and MRV (mammalian orthoreovirus) infections. Some viruses, such as influenza virus and HTLV-1 (Human T-lymphotropic virus 1), block the formation of granules. In addition, there are viruses like West Nile Virus, Hepatitis C Virus (HCV) or human Herpes viruses, which influence the functioning of the granules.