The role of serum hyaluronic acid determination in the diagnosis of liver diseases
The common pathway leading to liver fibrosis and cirrhosis is growing deposition of extracellular matrix (ECM). It results from molecular and histological rearrangement of collagens, glycoproteins and hyaluronans. Hyaluronic acid is a chief component of the extracellular matrix of connective tissues and plays the main structural role in the formation of ECM. The most important organ involved in the synthesis of hyaluronic acid is the liver. In this paper the meaning of hyaluronic acid in the diagnostics of liver diseases was discussed. Here, we focus on the described changes of hyaluronic acidconcentration in the pathological processes of the liver, including alcoholic and non-alcoholic liver diseases. The results of published clinical studies have shown its high diagnostic sensitivity, which probably enables an application in laboratory diagnosis.
Afdhal NH, Nunes D (2004) Evaluation of liver fibrosis: a concise review. Am J Gastroenterol 99: 1160-1174. doi: 10.1111/j.1572-0241.2004.30110.x
Ali SF, Onaivi ES, Dodd PR, et al. (2011) Understanding the Global Problem of Drug Addiction is a Challenge for IDARS Scientists.CurrNeuropharmacol 9: 2–7. doi: 10.2174/157015911795017245
Arain SA, Meo SA, Jamal Q (2011) Serum hyaluronic acid level does not reliably differentiate minimal and significant liver disease in chronic hepatitis C. Saudi Med J 32: 1241-1245.
Bataller, Brenner DA (2005) Liverfibrosis. J Clin Invest 115: 209–218. doi: 10.1172/JCI24282
Benhamou Y, Bochet M, Di Martino V, et al. (1999)Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients. The Multivirc Group. Hepatol Baltim Md 30: 1054–1058. doi: 10.1002/hep.510300409
Bierman HR, Hill BR, Reinhardt L, Emory E (1957). Correlation of serum lactic dehydrogenase activity with the clinical status of patients with cancer, lymphomas, and leukemias. Cancer Res 17: 660-667.
Bravo AA, Sheth SG, Chopra S (2001) Liver biopsy. N Engl J Med 344: 495-500. doi: 10.1056/NEJM200102153440706
Bullock C (1990) The biochemistry of alcohol metabolism- a brief review. Biochemical education 18: 62-66.
Chwist A, Hartleb M, Lekstan A, Kukla M, Gutkowski K, Kajor M (2014) A composite model including visfatin, tissue polypeptide-specific antigen, hyaluronic acid, and hematological variables for the diagnosis of moderate-to-severe fibrosis in nonalcoholic fatty liver disease: a preliminary study. Pol Arch Med Wewn 124: 704-712.
Crawford DH, Murphy TL, Ramm LE, et al. (2009) Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis. Hepatology 49: 418-425. doi: 10.1002/hep.22650
Deaciuc IV, McDonough KH, Bagby GJ, Spitzer JJ (1993) Alcohol consumption in rats potentiates the deleterious effect of Gram-negative sepsis on hepatic hyaluronan uptake. Alcohol Clin Exp Res 17: 1002-1008.
Deaciuc IV, Spitzer JJ, Shellito JE, D’Souza NB (1994) Acute alcohol administration to mice induces hepatic sinusoidal endothelial cell dysfunction. International Hepatology Communications 2: 81-86.
Dvorak K, Stritesky J, Petrtyl J, et al. (2014) Use of Non-Invasive Parameters of Non-Alcoholic Steatohepatitis and Liver Fibrosis in Daily Practice - An Exploratory Case-Control Study. PLoS One 9: e111551. doi: 10.1371/journal.pone.0111551
El-Bassiouni NE, Nosseir MM, Madkour ME, et al. (2012) Role of fibrogenic markers in chronic hepatitis C and associated hepatocellular carcinoma. Mol Biol Rep 39:6843-6850. doi: 10.1007/s11033-012-1509-z
Fairbanks K D. (2012)Alcoholic liver disease http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/hepatology/alcoholic-liver-disease/. November 2012.
Fitzpatrick E, Mitry RR, Quaglia A, Hussain MJ, DeBruyne R, Dhawan A (2010) Serum levels of CK18 M30 and leptin are useful predictors of steatohepatitis and fibrosis in paediatric NAFLD. J Pediatr Gastroenterol Nutr 51: 500–506. doi: 10.1097/MPG.0b013e3181e376be
Fontana RJ, Goodman ZD, Dienstag JL, et al. (2008) Relationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis C. Hepatology 47: 789-798. doi: 10.1002/hep.22099
Geramizadeh B, Janfeshan K, Saberfiroozi M (2008) Serum hyaluronic acid as a noninvasive marker of hepatic fibrosis in chronic hepatitis B. Saudi J Gastroenterol 14: 174-177. doi: 10.4103/1319-3767.43274
Gitlin N, Serio KM (1992) Ischemic hepatitis: widening horizons. Am J Gastroenterol 87: 831-836.
Gitto S, Villa E (2016) Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome after Liver Transplant. Int J Mol Sci 17: 490. doi: 10.3390/ijms17040490
Gressner AM, Rizk M, Chunfang G, Olav AG (2010) Potential novel biomarkers for monitoring the fibrogenic process in liver. Arab J Gastroenterol 10: S12-16.
Gudowska M, Gruszewska E, Panasiuk A, et al.(2015) Hyaluronic acid concentration in liver diseases. Clin Exp Med. doi: 10.1007/s10238-015-0388-8.
Gümüşay O, Ozenirler S, Atak A, et al. (2013) Diagnostic potential of serum direct markers and non-invasive fibrosis models in patients with chronic hepatitis B. Hepatol Res 43: 228-237. doi: 10.1111/j.1872-034X.2012.01057.x
Halfon P, Bourlière M, Pénaranda G, et al. (2005) Accuracy of hyaluronic acid level for predicting liver fibrosis stages in patients with hepatitis C virus. Comp Hepatol 4: 6. doi: 10.1186/1476-5926-4-6
Hsu YS, Chien RN, Yeh CT, et al. (2002) Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B. Hepatology 35: 1522–1527. doi: 10.1053/jhep.2002.33638
Kaux JF, Samson A, Crielaard JM (2016) Hyaluronic acid and tendon lesions. Muscles Ligaments Tendons J 5: 264-269. doi: 10.11138/mltj/2015.5.4.264
Korner T, Kropf J, GressnerAM (1996) Serum laminin and hyaluronan in liver cirrhosis markers of progression with high prognostic value. J Hepatol 25: 684-688.
Lebensztejn DM, Sobaniec-Lotowska ME, Kaczmarski M, Voelker M, Schuppan D (2006) Matrix-derived serum markers in monitoring liver fibrosis in children with chronic hepatitis B treated with interferon alpha. World J Gastroenterol 12: 3338-3343.
Li F, Zhu CL, Zhang H, et al. (2012) Role of hyaluronic acid and laminin as serum markers for predicting significant fibrosis in patients with chronic hepatitis B. Braz J Infect Dis 16: 9-14.
McHutchison JG, Blatt LM, de Medina M, Craig JR, Conrad A, Schiff ER, Tong MJ (2000) Measurement of serum hyaluronic acid in patients with chronic hepatitis C and its relationship to liver histology. Consensus Interferon Study Group. J Gastroenterol Hepatol 15: 945-951.
Mehta P, Ploutz-Snyder R, Nandi J, Rawlins SR, Sanderson SO, Levine RA (2008) Diagnostic accuracy of serum hyaluronic acid, FIBROSpect II, and YKL-40 for discriminating fibrosis stages in chronic hepatitis C. Am J Gastroenterol 103: 928-936. doi: 10.1111/j.1572-0241.2007.01761.x
Mima K, Beppu T, Ishiko T, et al. (2014) Preoperative serum hyaluronic acid level as a prognostic factor in patients undergoing hepatic resection for hepatocellular carcinoma. Br J Surg 101: 269-276. doi: 10.1002/bjs.9343
Mizuno M, Shima T, Oya H, et al. (2016) Classification of patients with nonalcoholic fatty liver disease using rapid immunoassay of serum type IV collagen compared with that using liver histology and other fibrosis markers. Hepatol Res doi: 10.1111/hepr.12710
Naor D (2016) Editorial: Interaction Between Hyaluronic Acid and Its Receptors (CD44, RHAMM) Regulates the Activity of Inflammation and Cancer. Front Immunol 7: 39. doi: 10.3389/fimmu.2016.00039
Naveau S, Raynard B, Ratziu V, et al. (2005) Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease. Clin Gastroenterol Hepatol 3:167-174.
Necas J, Bartosikova L, Brauner P, Kolar J (2008) Hyaluronic acid (hyaluronan): a review. Veterinari Medicina 8: 397- 411.
Nelson PK, Mathers BM, Cowie B, et al. (2011) Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews. Lancet 378: 571–583. doi: 10.1016/S0140-6736(11)61097-0
Nguyen-Khac E, Chatelain D, et al. (2008) Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests. Aliment Pharmacol Ther 28: 1188-1198. doi: 10.1111/j.1365-2036.2008.03831.x
Nunes D, Fleming C, Offner G, et al. (2005) HIV infection does not affect the performance of noninvasive markers of fibrosis for the diagnosis of hepatitis C virus-related liver disease. J Acquir Immune Defic Syndr 40: 538-544.
Nusgens BV (2010) Hyaluronic acid and extracellular matrix: a primitive molecule? Ann Dermatol Venereol 1: S3-8. doi: 10.1016/S0151-9638(10)70002-8
Parkes J, Guha IN, Harris S, Rosenberg WM, Roderick PJ (2012) Systematic review of the diagnostic performance of serum markers of liver fibrosis in alcoholic liver disease. Comp Hepatol 11: 5. doi: 10.1186/1476-5926-11-5
Parsian H, Rahimipour A, Nouri M, et al. (2010) Serum hyaluronic acid and laminin as biomarkers in liver fibrosis. J Gastrointestin Liver Dis 19:169-174.
Peters L, Mocroft A, Soriano V, et al. (2013) Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patients. PLoS One 8: e64283. doi: 10.1371/journal.pone.0064283
Resino S, Bellón JM, Asensio C, et al. (2010) Can serum hyaluronic acid replace simple non-invasive indexes to predict liver fibrosis in HIV/Hepatitis C coinfected patients? BMC Infect Dis 10: 244. doi: 10.1186/1471-2334-10-244
Rossi E, Adams LA, Bulsara M, Jeffrey GP (2007) Assessing liver fibrosis with serum marker models. Clin Biochem Rev 28: 3-10.
Rostami S, Parsian H (2013) Hyaluronic Acid: from biochemical characteristics to its clinical translation in assessment of liver fibrosis. Hepat Mon 14: e13787. doi: 10.5812/hepatmon.13787.
Salmon-Ceron D, Lewden C, Morlat P, et al. (2005) Liver disease as a major cause of death among HIV infected patients: role of hepatitis C and B viruses and alcohol. J Hepatol 42: 799–805.
Schanté C, Zuber G, Herlin C, Vandamme TF (2011) Chemical modifications of hyaluronic acid for the synthesis of derivatives for a broad range of biomedical applications. Carbohydrate Polymers 85: 469–489.
Schilsky ML. Hepatitis B “360” (2013) Transplantation Proceedings 45: 982–985.
Seven G, Karatayli SC, Köse SK, et al. (2011) Serum connective tissue markers as predictors of advanced fibrosis in patients with chronic hepatitis B and D. Turk J Gastroenterol 22: 305-314.
Shen Y, Shi G, Huang C, et al. (2015) Prediction of Post-Operative Liver Dysfunction by Serum Markers of Liver Fibrosis in Hepatocellular Carcinoma. PLoS One 10: e0140932. doi: 10.1371/journal.pone.0140932
Sowa JP, Heider D, Bechmann LP, Gerken G, Hoffmann D, Canbay A (2013) Novel algorithm for non-invasive assessment of fibrosis in NAFLD. PLoS One 8: e62439. doi: 10.1371/journal.pone.0062439
Stachowska E, Maciejewska D, Ossowski P, et al. (2013) Apolipoprotein E4 allele is associated with substantial changes in the plasma lipids and hyaluronic acid content in patients with nonalcoholic fatty liver disease. J Physiol Pharmacol 64: 711-717.
Stickel F, Poeschl G, Schuppan D, et al. (2003) Serum hyaluronate correlates with histological progression in alcoholic liver disease. Eur J Gastroenterol Hepatol 15: 945-950.
Valva P, Casciato P, Diaz Carrasco JM, et al. (2011) The role of serum biomarkers in predicting fibrosis progression in pediatric and adult hepatitis C virus chronic infection. PLoS One 6: e23218. doi: 10.1371/journal.pone.0023218
Yu X, Deng M, Zhang K, Xie XS (2015) Clinical Analysis of 36 Elderly Patients with Schistosome-Induced Liver Disease Complicated by Hepatitis E. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing ZaZhi. 33: 258-263.
Acta Biochimica Polonica is an OpenAccess quarterly and publishes four issues a year. All contents are distributed under the Creative Commons Attribution-ShareAlike 4.0 International (CC BY 4.0) license. Everybody may use the content following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
Copyright for all published papers © stays with the authors.
Copyright for the journal: © Polish Biochemical Society.