Mechanisms of type I interferon action and its role in infections and diseases transmission in mammals

  • Weronika Ratajczak student of Scientific Circle of Microbiologists, Faculty of Biology, University of Szczecin
  • Paulina Niedźwiedzka-Rystwej Department of Immunology, Faculty of Biology, University of Szczecin, Poland
  • Beata Tokarz-Deptuła Department of Immunology, Faculty of Biology, University of Szczecin, Poland
  • Wiesław Deptuła Department of Microbiology, Faculty of Biology, University of Szczecin, Poland
Keywords: interferon, signaling pathway, infection, mammal


Interferons (IFN) are pivotal regulators of immunological processes. The paper describes mainly type I interferons -α and –β and its recently recounted signaling pathways, especially ISG – interferon stimulated genes, having a crucial role in regulating IFN recruitment. Moreover, the paper shows the data on the role of interferons -α and –β in infections – not only commonly known viral infections, but also bacterial, fungal and parasitic. 


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