When small RNAs become smaller: non - canonical functions of snoRNAs and their derivatives

  • Anna Maria Mleczko Institute of Bioorganic Chemistry Polish Academy of Sciences
  • Kamilla Bąkowska-Żywicka Institute of Bioorganic Chemistry Polish Academy of Sciences
Keywords: small RNAs, snoRNAs, sdRNAs, microRNAs, regulatory RNAs


Small nucleolar RNAs (snoRNAs) are molecules placed in the cell nucleolus and in Cajal bodies. Many scientific reports clearly show that snoRNAs are not only responsible for modifications of other RNAs but also possess multiple other functions such as metabolic stress regulation or modulation of alternative splicing. Full-length snoRNAs as well as small RNAs derived from snoRNAs have been implied in human diseases such as cancer or Prader – Willi Syndrome.  In this review we would like to describe these non – canonical roles of snoRNAs and their derivatives  with the emphasis on their role in human diseases. 


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