Ezetimibe prevents myocardial remodeling in an obese rat model by inhibiting inflammation

  • Xiao-Xing Li Qilu Hospital, Shandong University
  • Lang Zhao Qilu Hospital, Shandong University
  • Ying Chang Qilu Hospital, Shandong University
  • Bao-Shan Liu Qilu Hospital, Shandong University
  • Feng Xu Qilu Hospital, Shandong University
  • Cheng Zhang Qilu Hospital, Shandong University
  • Xiao-Ping Ji Qilu Hospital, Shandong University
  • Yu-Guo Chen Qilu Hospital, Shandong University
  • Chuanbao Li Qilu Hospital, Shandong University
Keywords: obese, inflammation, remodeling, ezetimibe, IL-6

Abstract

Inflammation plays an important role in obesity. This study aimed to investigate the effects of ezetimibe on improvement of inflammation and myocardial remodeling in obese rats. A rat model of obesity was established and myocardial damage was examined by transmission electron microscopy and Masson staining. Twenty obese rats were divided into two groups (n=10): obese group and ezetimibe group. Ten SD rats were used as controls. Western blot was used to monitor the expression of P-p38MAPK, interleukin-6. Immunohistochemical staining was used to monitor the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1.In obese group rats, we found increased inflammation factors and myocardial hypertrophy. In ezetimibe group, we found decreased expression of inflammation factors and improvement of myocardial remodeling compared to obese group. Mechanistically, we found that ezetimibe decreased P-p38MAPK, interleukin-6, intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 levels in the hearts of obese rats. Taken together, these results indicate that ezetimibe may improve myocardial remodeling in obese rats by inhibiting inflammation. 
Published
2018-09-08
Section
Articles